4 ACO DMT
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4-Acetoxy-N, N-dimethyltryptamine (also known as 4-AcO-DMT, 4-Acetoxy-DMT, O-Acetylpsilocin, and psilocin) is a novel psychedelic substance of the tryptamine class. 4-AcO-DMT is chemically similar to psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). It belongs to a group known as the substituted tryptamines which act by stimulating serotonin receptorsin the brain.
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What is 4-ACO-DMT
4 ACO DMT is a psychoactive drug which they produce synthetically. Suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies. Since people believe they are prodrugs of psilocin.
It is the acetylated form of the psilocybin mushroom alkaloid psilocin and is a lower homolog of 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT.
4-ACO-DMT and several other esters of psilocin were originally patented on January 16, 1963 by Sandoz Ltd. via Albert Hofmann & Franz Troxler. Despite this fact, 4 ACO DMT remains a psychedelic with a limited history of use prior to its release as a grey area compound on the online research chemical market.
However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
There are, however, claims of subjective differences in effect between the acetylated and non-acetylated forms of psilocin. Some users report that it lasts slightly longer than psilocin. While others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by 4 ACO DMT more closely resemble those produced by DMT than those produced by psilocin. These differences could be possible if 4-ACO-DMT is active itself and not merely as a prodrug.
Effects of 4 ACO DMT
Cathinone derivatives can easily pass through the brain–blood barrier and because of structural similarities with phenethylamine, they display psychoactive properties. The most important mechanism of action of cathinones is inhibiting of protein-transporting monoamines (dopamine, noradrenaline and serotonin) of the synaptic gap. The sympathomimetic syndrome dominates in a clinical picture.
Since then, further cathinones were synthesized and marketed, posing a real threat to public health. Cathinones cause a number of side effects associated with the cardiovascular system (increased heart rate, arrhythmias, increased blood pressure, myocardial ischemia with ECG changes and chest pain, myocarditis and sudden cardiac death); the coagulation system(disseminated vascular coagulation syndrome and decrease in platelet count); the nervous system (sleep disturbances, headache, vision disorder, mydriasis, paresthesia, convulsions and hyperthermia); and the gastrointestinal tract (nausea, vomiting and abdominal pain).
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These compounds also cause mental disorders and metabolic disorders (including metabolic acidosis, dehydration, electrolyte disorders and nitrogen body retention). The most commonly reported adverse reactions for cathinones are cardiovascular, nervous, and psychiatric disorders (including acute psychoses).
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